mntH [2017-05-09 15:36:34]

manganese transporter (proton symport)

locus: BSU04360

pI: 9.89

mw: 45.52 kDa

protein length: 425 aa

gene length: 1275 bp

function: manganese uptake

product: manganese transporter (proton symport))

essential: no

synonyms: ydaR

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 491,147 → 492,424

The protein

Protein family

• NRAMP family (according to Swiss-Prot)

Structure

• [PDB|4WGV] (from ''Staphylococcus capitis'', 40% identity) [Pubmed|25326704]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|353DADE8E57A0F1895CCEB62701F9273EEB5EB45|mntH]
  description: [Pubmed|10760146]

  regulatory mechanism

  • [protein|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR]: repression, [Pubmed|10760146], in [regulon|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR regulon]

  regulation

  • repressed at high Mn(II) concentrations (MntR) [Pubmed|10760146]

Biological materials

Mutant

• MGNA-C116 (ydaR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2114 NBRP B. subtilis, Japan]

Labs working on this gene/protein

• [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

References

• 10760146,12950915,10760146,25326704